Fare Guide
Estimated lowest fares found within 7 days
The cheapest airline(s) flying from Des Moines to Chicago is American Airlines.
Travel Period: June 2025 - May 2026
The cheapest month(s) to fly from Des Moines to Chicago is June.
The cheapest day(s) of the week to fly from Des Moines to Chicago is Wednesday.
Flight Schedules
Last Updated: Fri, 2 May, 2025
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The fastest flight time for direct flights from Des Moines to Chicago is 1 hour 22 minutes. Check latest flight schedules & prices on Wego.
The flight distance between Des Moines and Chicago is 497km. Check all available flights on Wego.
The earliest flight of the day departs at 05:32. The last flight of the day departs at 05:32. See the full list of flight times on Wego.
There are 2 airlines that offer direct flights from Des Moines to Chicago. Find out the list of airlines on Wego.
Popular Destinations From Chicago
Popular Destinations From Des Moines
Popular Hotels in Chicago
- Clarion Inn Elmhurst - Oak Brook near I-88, I-290, I-294
- The Royal Sonesta Chicago Downtown
- Club Quarters Hotel Central Loop
- The Ritz-Carlton, Chicago
- Fairmont Chicago at Millennium Park Gold Experience
- Swissôtel Chicago
- Pendry Chicago
- Hotel Felix River North/Magnificent Mile
- Hotel Saint Clair
- Best Western River North Hotel
